Psychotropic activity of cholecystokinine tetrapeptide analogs

Autor:	N. V. Pankratova, O. B. Petrichenko, Pal'keeva Me, T.V. Proskuryakova, I. P. Anokhina, Zh. D. Bespalova
Rok vydání:	1998
Předmět:	Behavioral test Anxiogenic Tetrapeptide business.industry Medicine General Medicine Motor activity Pharmacology business General Biochemistry Genetics and Molecular Biology Cholecystokinin Nootropic
Zdroj:	Bulletin of Experimental Biology and Medicine. 125:573-575
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02445243
Popis:	Psychotropic activity of two cholecystokinin analogs Trp-R1-Asp-Phe-NH2 and R2-Trp-R3-Asp-Phe-NH2 is studied using behavioral tests. Both analogs have no effect on motor activity. Trp-R1-Asp-Phe-NH2 in doses of 0.1 and 0.3 mg/kg exhibits anxiogenic activity and impairs learning (only in a dose of 0.1 mg/kg) of experimental animals. R2-Trp-R3-Asp-Phe-NH2 possesses no anxiogenic activity and in doses of 0.1 and 0.3 mg/kg promotes learning, which attests to its nootropic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eaca26beb03b85cff78e27553c0a5231 https://doi.org/10.1007/bf02445243 Zobrazit plný text záznamu Full text from SpringerLink