ChemInform Abstract: A New Protecting Group for the Synthesis of Complex Sulfonates

Autor:	Meiqiang Xie, Theodore S. Widlanski
Rok vydání:	2010
Předmět:	endocrine system Chemistry Nanotechnology General Medicine Alkylation Adenosine Uridine chemistry.chemical_compound Sulfonate medicine Nucleic acid Organic chemistry heterocyclic compounds sense organs Protecting group hormones hormone substitutes and hormone antagonists Isopropyl medicine.drug
Zdroj:	ChemInform. 27
ISSN:	0931-7597
Popis:	The isobutyl ester proved to be a useful protecting group for the construction of sulfonate-containing analogs of nucleosides. The syntheses of useful uridine or adenosine 3′-C-methanesulfonate analogs 1a or 1b that fail when using ethyl or isopropyl sulfonate esters, are readily accomplished with the isobutyl ester as a protecting group. In addition, alkylation reactions to give homologated sulfonates such as 2 are also much more facile when using the isobutyl protecting group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eab36130100c736192d9acfc3d2a5d70 https://doi.org/10.1002/chin.199640210 Zobrazit plný text záznamu Plný text