Identification and Purity Control of Thioacridine Derivatives by Gas and Capillary Liquid Chromatography with Mass Spectrometric Detection

Autor:	Martin Štícha, Irena Němcová, Ivan Jelínek, Blanka Kutnerová
Rok vydání:	2004
Předmět:	Electrospray Chemical ionization Chromatography Chemistry Electrospray ionization Biochemistry (medical) Clinical Biochemistry Analytical chemistry Mass spectrometry Biochemistry Analytical Chemistry Electrochemistry Mass spectrum Gas chromatography Direct electron ionization liquid chromatography–mass spectrometry interface Spectroscopy Electron ionization
Zdroj:	Analytical Letters. 37:263-272
ISSN:	1532-236X 0003-2719
Popis:	Mass spectrometry combined with gas chromatography (GC‐MS) or capillary liquid chromatography (CLC‐MS) was successfully utilized for structural characterization and purity control of synthesized biologically active thioacridine derivatives. Obtained results document sufficient selectivity of GC‐MS and CLC‐MS towards structurally related impurities and degradation products accompanying the compound of desire in analyzed substances. Based on electron impact ionization mass spectra an attempt to estimate their exact structures was made. The results of structure elucidation were confirmed by more detailed fragmentation studies based on (MS)2 and (MS)3 electrospray ionization mass spectra.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ea9e9612826915ca89ecdf09e1172cca https://doi.org/10.1081/al-120027791 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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