Factors influencing the serum cholesterol and ?-lipoprotein levels in fasting rabbits
| Autor: | D. Yu. Udalov, V. A. Tsyganok |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Starvation
medicine.medical_specialty Cholesterol business.industry General Medicine Pyridoxine General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine lipids (amino acids peptides and proteins) Thiamine Pyridoxine Deficiency medicine.symptom Amphetamine business Diazepam Serum cholesterol medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 83:817-819 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00798883 |
| Popis: | The effect of starvation under ordinary conditions, in the presence of a deficiency of pyridoxine (administration of 4-deoxypyridoxine) and thiamine (administration of hydroxythiamine), and also during administration of neurotropic drugs 9amphetamine, diazepam) was studied in male rabbits. Starvation for 7–10 days led to an increase in the serum cholesterol and β-lipoprotein concentration. Pyridoxine deficiency and administration of amphetamine caused a greater increase in the level of cholesterol and, in particular, of β-lipoproteins. Thiamine deficiency and administration of diazepam, on the other hand, had a restraining effect on the increase in the cholesterol and β-lipoprotein levels in hunger stress. Prophylactic administration of the preparation Aerovit helped to reduce the severity of the metabolic changes. The cholesterol concentration in the liver of the fasting animals was increased by an especially marked degree during amphetamine administration and pyridoxine deficiency; administration of Aerovit prevented the increased accumulation of cholesterol in the liver. Differences in the serum and liver cholesterol concentrations must be attributed to changes in cholesterol biosynthesis in hunger stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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