The efficacy of splenic hilar lymph node dissection in advanced gastric cancer
| Autor: | Tetsuro Toriumi, Etsuro Bando, Satoshi Kamiya, Rie Makuuchi, Yutaka Tanizawa, Masanori Terashima, Taiichi Kawamura |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty Splenic Hilar Lymph Node Upper gastrointestinal series medicine.diagnostic_test Esophagogastroduodenoscopy business.industry medicine.medical_treatment Standard treatment Splenectomy Gastroenterology Curvatures of the stomach 03 medical and health sciences Dissection 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Internal medicine medicine Gastrectomy business 030215 immunology |
| Zdroj: | Journal of Clinical Oncology. 37:112-112 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | 112 Background: Total gastrectomy with splenectomy for splenic hilar lymph node (No.10 LN) dissection had been a standard treatment for proximal advanced gastric cancer in Japan. The efficacy of No. 10 LN dissection with splenectomy for advanced gastric cancer without the greater curvature invasion was denied by a randomized controlled trial, JCOG0110. However, JCOG0110 did not include the patients with greater curvature invasion. Therefore, we aimed to clarify the role of No. 10 LN dissection in patients with proximal advanced gastric cancer invading the greater curvature. Methods: A total of 273 patients with proximal advanced gastric cancer who underwent curative total gastrectomy with splenectomy from 2002 to 2013 were included. We reviewed esophagogastroduodenoscopy and upper gastrointestinal series for evaluation of clinical tumor localization and classified the patients into with greater curvature invasion group (G group, n = 108) or without invasion group (NG group, n = 165). The incidence and therapeutic value index (TVI) of No. 10 LN were compared between the groups. Results: Patients in the G group had more advanced T stage, undifferentiated histology, and larger tumor size than those in the NG group. However, there was no difference in survival between the groups; 5-year overall survival (5-OS) was 66.3% in the G group and 69.1% in the NG group (p = 0.570). The incidence of No.10 LN metastasis was significantly higher in the G group (10.2%) than that in the NG group (3.0%) (p = 0.028). TVI for No.10 LN dissection was higher in the G group (5.6) than that in the NG group (0.6). The survival of the patients with No.10 LN metastasis tended to be better in the G group, although it did not reach statistical significance (5-OS: 54.5% in G group vs. 20.0% in NG group, p = 0.336). Conclusions: It is suggested that splenic hilar LN dissection has a favorable effect on survival in patients with proximal gastric cancer invading the greater curvature. |
| Databáze: | OpenAIRE |
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