Serum Zinc, Iron, and Copper Concentrations during Typhoid Fever in Man: Effect of Chloramphenicol Therapy

Autor:	Robert W. Wannemacher, R S Pekarek, Karen A. Bostian, William R. Beisel, R. M. Kluge, Richard B. Hornick, Herbert L Dupont
Rok vydání:	1975
Předmět:	Salmonella medicine.diagnostic_test business.industry Chloramphenicol Biochemistry (medical) Clinical Biochemistry Cefazolin Physiology medicine.disease Salmonella typhi medicine.disease_cause Typhoid fever Microbiology medicine Serum iron Gentamicin business Volunteer medicine.drug
Zdroj:	Clinical Chemistry. 21:528-532
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/21.4.528
Popis:	In volunteers experimentally infected with Salmonella typhi, serum iron and zinc concentrations became significantly depressed and there was a concomitant rise in serum copper before the onset of overt clinical illness. However, after several days of fever and the initiation of chloramphenicol therapy, serum iron and zinc concentrations significantly increased. Additional studies—in volunteers with typhoid fever treated with chloramphenicol, in a volunteer with typhoid fever receiving cefazolin and gentamicin, and in untreated rhesus monkeys infected with Salmonella typhimurium—provided evidence that the increase in serum iron concentration during the febrile phase was the result of chloramphenicol therapy, whereas the increase in serum zinc concentrations was a disease-related phenomenon. The importance of trace-metal monitoring during infectious disease and chemotherapy is discussed
Databáze:	OpenAIRE
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