Association between IGF1 gene single nucleotide polymorphism (rs5742612) and adolescent idiopathic scoliosis: a meta-analysis
Autor: | Yinshuang Zou, Ming Guan, Shutao Gao, Chongyang Zhang, Huang Fang, Huan Wang |
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Rok vydání: | 2016 |
Předmět: |
030222 orthopedics
medicine.medical_specialty education.field_of_study Web of science business.industry Population Single-nucleotide polymorphism Idiopathic scoliosis Cochrane Library Surgery 03 medical and health sciences 0302 clinical medicine Sample size determination Internal medicine Meta-analysis medicine Orthopedics and Sports Medicine business education Gene 030217 neurology & neurosurgery |
Zdroj: | European Spine Journal. 26:1624-1630 |
ISSN: | 1432-0932 0940-6719 |
Popis: | Insulin-like growth factor 1 (IGF1) gene single nucleotide polymorphism (rs5742612) has been associated with adolescent idiopathic scoliosis (AIS) in several studies with limited sample size and inconsistent outcomes. So we perform this meta-analysis to assess the precise association between IGF1 gene single nucleotide polymorphism (rs5742612) and AIS. We systematically searched Pubmed, Embase, Web of Science and Cochrane Library up to January 19, 2016 to obtain relevant studies using our research strategy. Four articles all belonging to case–control studies were included in our meta-analysis. A total of four studies containing 763 cases and 559 controls satisfied the inclusion criteria after judgment by two reviewers. No significant associations were detected between IGF1 gene single nucleotide polymorphism (rs5742612) and AIS (T vs. C, OR = 1.10, 95 % CI 0.91–1.34, p = 0.32; TT vs. CC: OR = 1.28, 95 % CI 0.82–2.02, p = 0.28; TC vs. CC: OR = 1.29, 95 % CI 0.82–2.06, p = 0.27; TT/TC vs. CC: OR = 1.28, 95 % CI 0.83–1.98, p = 0.27; TT vs. TC/CC: OR = 1.06, 95 % CI 0.82–1.36, p = 0.66). IGF1 gene single nucleotide polymorphism (rs5742612) is not significant associated with susceptibility to AIS in either Asian or Caucasian populations. However, IGF1 gene rs5742612 may be associated with severity of AIS. Further studies with larger sample size and different population groups involving the relationship are required to confirm the potential association. |
Databáze: | OpenAIRE |
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