Inositol levels in post mortem brain samples of Alzheimer's patients
| Autor: | Galila Agam, Michael Davidoson, V. Haroutunian, J. Shapiro, Hady Shimon |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
Pathology medicine.medical_specialty business.industry Posterior parietal cortex medicine.disease Central nervous system disease chemistry.chemical_compound Cerebrospinal fluid medicine.anatomical_structure chemistry Cerebral cortex Cortex (anatomy) medicine Inositol Alzheimer's disease business Biological Psychiatry Post-mortem interval |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 22:1241-1250 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/s0278-5846(98)00079-7 |
| Popis: | 1. 1. Free inositol levels in occipital and parietal cortex of Alzheimer's Disease (AD) patients were reported to be significantly elevated by 10–35% compared with matched controls, studied by magnetic resonance spectroscopy (MRS) during life. 2. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls. 3. 3. The present study shows non-significant trends of 13% increase in frontal cortex and 5% and 21% decrease in occipital cortex and cerebellum respectively, in post mortem brain specimens of AD patients measured gas chromatographically (GC). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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