Design, synthesis and anticancer evaluation of 2-Amino pyrimidine linked 7-Azaindzole derivatives

Autor:	Rajasekhar Chekkara, Mandava Venkata Basaveswara Rao, E. Susithra, Sobha Rani Tenkayala, Venkata Reddy Gorla, Reddymasu Sireesha
Rok vydání:	2020
Předmět:	Pyrimidine 010405 organic chemistry Chemistry Positive control General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Design synthesis Biochemistry Cell culture Ic50 values MTT assay skin and connective tissue diseases Human cancer
Zdroj:	Chemical Data Collections. 29:100513
ISSN:	2405-8300
DOI:	10.1016/j.cdc.2020.100513
Popis:	A series of 2-Aminopyrimidine linked 7-Azaindzole derivatives were designed, synthesized and evaluated for their anticancer activity against MCF-7, A549 and MDA-MB-231 human cancer cell lines by MTT assay method. The compound 11g showed potent anticancer activity against MCF-7, A549, MDA-MB-231 cell lines with IC50 values of 0.34 µM, 0.11 µM and 2.33 µM respectively than the positive control, Adiramycin. Compounds 11b, 11g, 11h and 11j also showed more potent activity than control, Adiramycin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ea7c7bb62e791b6ca459909fa60c4a51 https://doi.org/10.1016/j.cdc.2020.100513 Zobrazit plný text záznamu Full Text from ScienceDirect