SINGLE NUCLEOTIDE POLYMORPHISM OF ADIPONECTIN GENE (+276G > T) AND EXPRESSION OF INSULIN-RESISTANT STATE COMPONENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
| Autor: | Maryana Gorshunska, Yuri Karachentsev, Nona Kravchun, L. A. Atramentova, A. I. Gladkih, Nataliya Krasova, Zhanna Leshchenko, T. V. Tyzhnenko, Yu. A. Opaleiko, A. K. Pochernyayev, V. V. Poltorak |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Problems of Endocrine Pathology. 44:7-17 |
| ISSN: | 2518-1432 2227-4782 |
| DOI: | 10.21856/j-pep.2013.2.01 |
| Popis: | Single nucleotide polymorphism +276G > T of adiponectin gene (ADIPOQ) in type 2 diabetesmellitus patients (n=544) and healthy habitants (n = 215) of Kharkiv was studied. There wereno significant differences of single nucleotide polymorphism +276 G > T frequencies for patients(pG = 0.691; pT = 0,309) and healthy subjects (pG = 0,601; pT = 0,399). However diabetic patients hadincreased percentage of homozygote TT and decreased percentage of homozygote GG. Homozygosityin the minor allele T enhances significantly risk of disease in general population (OR 1,98; 95 %CI 1,14–3.32, p < 0.05) and homozygosity in the major allele G creates protective effect (OR 0,66; 95 %CI 0,48–0.90, p < 0.05). Functional meaning of single nucleotide polymorphism in the locus +276G > Tof ADIPOQ gene for hypoadiponectinemia genesis was verified as complementary to determiningimpact of diabetic endophenotype (hyperinsulinemia, insulin resistance, gluco- and lipotoxicity, centraltype of fat distribution). |
| Databáze: | OpenAIRE |
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