Photo(chemo)therapy of mastocytosis; a case report
| Autor: | Valvo, Beatrice, Grasso, Vincenzo, Pezzini, Claudia, Merante, Serena, Brazzelli, Valeria |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| DOI: | 10.6092/2039-1404.126.1652 |
| Popis: | Mastocytosis is defined as a heterogeneous group of rare disorders characterized by abnormal expansion and accumulation of mast cells in the skin (cutaneous mastocytosis) and/or in visceral organs, such as bone marrow, lymphnodes, liver, spleen and gastrointestinal tract (systemic mastocytosis). The skin is the organ most often involved in all forms of mastocytosis and lesions most commonly present as red-brownish and pruriginous macules or papules. Clinical manifestations vary widely and the main symptoms are related to the local burden and release of secretory mediators from mast cells, with mild-high pruritus being by far the most common cutaneous symptom. The mainstay of treatment in indolent forms, such as the cutaneous mastocytosis, are anti-mediators drugs, with the aim to minimize the massive release of histamine and other major secretory products and provide relief of pruritus. For this reason the basis of therapy is a combination of H1- and H2-antihistamines, while second-line treatments comprise PUVA-therapy (long-wave ultraviolet radiation plus psoralen) and narrowband UVB phototherapy (NB-UVB). We present the case of a patient with mastocytosis that benefit from both PUVA and NB-UVB. Bollettino della Società Medico Chirurgica di Pavia, Vol 126, N° 3 (2013) |
| Databáze: | OpenAIRE |
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