Aescin nanoparticles prepared using SEDS: Composition stability and dissolution enhancement
| Autor: | Dan Zhou, Jingfu Jia, Yaping Zhao, Wang Jie, Fahuan Ge, Kerong Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Aescin
Chemistry General Chemical Engineering Analytical chemistry Active components Nanoparticle 02 engineering and technology Sodium aescinate 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Supercritical fluid 0104 chemical sciences chemistry.chemical_compound Composition (visual arts) Physical and Theoretical Chemistry 0210 nano-technology Dispersion (chemistry) Dissolution |
| Zdroj: | The Journal of Supercritical Fluids. 130:267-272 |
| ISSN: | 0896-8446 |
| DOI: | 10.1016/j.supflu.2017.06.016 |
| Popis: | Aescin nanoparticles (ANPs) were prepared using solution-enhanced dispersion by supercritical fluids (SEDS) in order to improve the dissolution properties of aescin and avoid complicated salt-forming procedures. Because aescin is a mixture, the effects of the operating conditions on the composition of the ANPs were first investigated. The compositional ratio of the four dominant active components in aescin changed with the pressure at low solution concentrations (5 mg/mL), but remained constant at higher concentrations (>10 mg/mL). Spherical ANPs with an average diameter below 50 nm was obtained at 12 MPa with solution concentration between 10 to 15 mg/mL. The morphology of ANPs was primarily influenced by the concentration and pressure but not affected by the nozzle diameter. The dissolution of aescin was increased by near 5.5 times from raw aescin to ANPs. Compared with the sodium aescinate, the ANPs exhibited the similar dissolution, but had a moderate initial dissolution burst. |
| Databáze: | OpenAIRE |
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