ABERRANT TELOMERE LENGTH AND MITOCHONDRIAL DNA COPY NUMBER IN SUICIDE COMPLETERS

Autor: Akitoyo Hishimoto, Ikuo Otsuka, Ichiro Sora, Naofumi Shimmyo, Shuken Boku, Takeshi Izumi
Rok vydání: 2019
Předmět:
Zdroj: European Neuropsychopharmacology. 29:S863-S864
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2017.08.148
Popis: Background Short Telomere Length (TL) and mitochondrial DNA copy number (mtDNAcn) alterations in individuals under psychological stress, and with various psychiatric diseases. However, no study has examined whether aberrant TL or mtDNAcn occur in completed suicide, one of the most serious outcomes of mental illnesses. Methods TL and mtDNAcn in post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20 brains) and 560 samples from control subjects (peripheral bloods from 535 healthy individuals; 25 post-mortem brains) were analysed by PCR method. Results Suicide completers had significantly shorter TL and higher mtDNAcn of peripheral bloods with sex/age-dependent differences (shorter TL was more remarkably in female/young suicides; higher mtDNAcn more so in male/elderly suicides). The normal age-related decline of TL and mtDNAcn were significantly altered in suicide completers. Furthermore, shorter TL and lower mtDNAcn of post-mortem prefrontal cortex were seen in suicide completers compared to controls. Discussion Our results indicate that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.
Databáze: OpenAIRE
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