Relationship between spatial structure and pharmacological activity of a series of ?-adrenomimetics
| Autor: | B. S. Zhorov, V. A. Govyrin |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Series (mathematics)
Chemistry Stereochemistry Spatial structure Substituent Diastereomer Biological activity Condensed Matter Physics Atomic and Molecular Physics and Optics Reduction (complexity) chemistry.chemical_compound Adrenomimetic Computational chemistry lipids (amino acids peptides and proteins) Physical and Theoretical Chemistry |
| Zdroj: | International Journal of Quantum Chemistry. 16:517-525 |
| ISSN: | 1097-461X 0020-7608 |
| DOI: | 10.1002/qua.560160310 |
| Popis: | All equilibrium conformations of a series of N-alkyl-α-alkyl derivatives of noradrenaline and their synthetic precursors—phenylaminoketones—have been calculated. It has been shown that spasmodic changes in bronchodilating activity of the catecholamines, observed with the increase in α-alkyl substituent size, may arise from the difference in the ratio of diastereoisomers produced by reduction of aminoketones. |
| Databáze: | OpenAIRE |
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