How erythrocyte volume is regulated, or what mathematical models can and cannot do for biology

Autor:	I. O. Pivovarov, N. V. Kalyagina, N. O. Korunova, F. I. Ataullakhanov, I. S. Spiridonov, M. V. Martinov
Rok vydání:	2009
Předmět:	biology Mathematical model Membrane permeability ATPase Cell volume Biophysics Cell Biology Biochemistry Cell biology Cell membrane Red blood cell medicine.anatomical_structure Volume (thermodynamics) biology.protein medicine Na+/K+-ATPase
Zdroj:	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 3:101-115
ISSN:	1990-7494 1990-7478
DOI:	10.1134/s1990747809020019
Popis:	Modern concepts of the red blood cell (RBC) volume regulation are considered. It is shown that the system of ion pumps and channels in the cell membrane ensures the physiological value of volume with a pre- cision of about 10% even at 5- to 7-fold variations of passive membrane permeability for ions. Particular atten- tion is paid to mathematical models for evaluation of the role of different molecular mechanisms in the RBC volume control. It is shown that many questions, for example, 'why the Na + ,K + -ATPase pumps the ions in oppo- site directions' or 'what is the physiological role of Ca 2+ -activated K + -channels', cannot be answered without adequate mathematical models of such complex control systems as cell volume control.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ea54f7280c0182241112edc7692a6a3c https://doi.org/10.1134/s1990747809020019 Zobrazit plný text záznamu Full text from SpringerLink