Holoprosencephaly
| Autor: | PJ Bullen, SC Robson |
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| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Fetal and Maternal Medicine Review. 12:1-21 |
| ISSN: | 1469-5065 0965-5395 |
| DOI: | 10.1017/s0965539501000110 |
| Popis: | Holoprosencephaly (HPE) is an uncommon and clinically severe abnormality of forebrain development, resulting from failure of septation, or cleavage, of the midline forebrain structures. It encompasses a range of brain pathology classified as lobar, semilobar or alobar HPE reflecting increasing degrees of failed septation. The closely related development of the mid-face area is frequently disturbed, with coexisting facial phenotypes ranging from cyclopia to normal. |
| Databáze: | OpenAIRE |
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