The in vivo Formation of Mutagenic N-Nitroso Compounds from Methamphetamine and Ephedrine

Autor:	Mariko Morita, Nozomi Takemura, Hidesuke Shimizu, Hiroaki Ando, Katsuhiko Machida
Rok vydání:	1984
Předmět:	Chromatography Nitroso Compounds Chemistry Stereochemistry Hamster General Medicine Urine Methamphetamine Ames test chemistry.chemical_compound In vivo medicine Nitrite Ephedrine medicine.drug
Zdroj:	Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene). 39:573-580
ISSN:	1882-6482 0021-5082
DOI:	10.1265/jjh.39.573
Popis:	The mutagenicity of N-nitrosomethamphetamine and N-nitrosoephedrine synthesized from methamphetamine and ephedrine in our laboratory was proved to be significant by the modified method of the Ames assay using Salmonella typhimurium TA100 and TA98 and E. coli WP2 uvrA/pKM in the presence of hamster S9.The formation of N-nitrosomethamphetamine from methamphetamine and nitrite when incubated in vitro in the human urine or in human gastric juice was found. On the other hand, N-nitrosomethamphetamine was detected from the urine of methamphetamine addicts.The identification of N-nitrosomethamphetamine was carried out by GC/MS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ea4972e39bc28fb9b3b8900d243a10e3 https://doi.org/10.1265/jjh.39.573 Zobrazit plný text záznamu