Ocena odsetka limfocytów CD19+CD5+ w przerosłych migdałkach gardłowych u dzieci chorych na wysiękowe zapalenie ucha środkowego
| Autor: | Edwina Kasprzycka, Bożena Skotnicka, Karol Ratomski, Beata Żelazowska-Rutkowska, Jolanta Wysocka, Sławomir Anisimowicz |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry hemic and immune systems Adenoid CD19 Otitis medicine.anatomical_structure Otorhinolaryngology Effusion hemic and lymphatic diseases otorhinolaryngologic diseases biology.protein Middle ear Medicine Respiratory system CD5 medicine.symptom Ligation business |
| Zdroj: | Otolaryngologia Polska. 61:962-966 |
| ISSN: | 0030-6657 |
| DOI: | 10.1016/s0030-6657(07)70561-9 |
| Popis: | Summary Introduction Otitis media with effusion and hypertrophied adenoid are still common diseases in childhood. Adenoid has particular meaning to develop of immunological response to inflammations in upper respiratory inclusive middle ear. The origin CD19+CD5+ B cells remains controversial. The differentiation response to ligation of CD5 resulting in apoptosis or proliferation lymphocytes. The aim of this study was compare the percentage of CD19+CD5+ lymphocytes in hypertrophied adenoid tissue at children with otitis media with effusion to comparative group without inflammatory state in middle ear. Material and methods We tested 37 children in examine group with hypertrophied adenoid and otitis media with effusion (OME), and 32 children in comparative group only with hypertrophied adenoid (HA). We also divided both groups into two groups, above 5 and over 5 years old. We made the research by flow cytometry method. We used anty-CD19 and anty-CD5 monoclonal antibodies to examinations. Results In this study we showed significantly higher percentage of the CD19+CD5+ lymphocytes at children with examined group (OME 22.12 ± 4.31%) than in comparative group (HA 19.16 ± 4.32%), p Conclusions The significant higher percentage of B lymphocytes with expressions of CD5+ receptor in hypertrophied adenoid tissue at children with otitis media with effusion are important to develop of early immunological response to inflammatory state in middle ear. |
| Databáze: | OpenAIRE |
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