Activated nitriles in heterocyclic synthesis: Novel Synthesis of Pyrimidine and of Pyridine Derivatives

Autor:	Mohamed Hilmy Elnagdi, Nabila A. Ismail, Zaghloul E. Kandeel, Khalid Mohamed Hassan
Rok vydání:	1984
Předmět:	chemistry.chemical_compound Aniline Thiourea chemistry Pyrimidine Yield (chemistry) Reagent Pyridine Organic chemistry Guanidine Malononitrile
Zdroj:	Journal f�r Praktische Chemie. 326:248-252
ISSN:	1521-3897 0021-8383
DOI:	10.1002/prac.19843260208
Popis:	α-Cyanochalcone reacted with thiourea and guanidine to yield the corresponding pyrimidine derivatives 2 and 4. On the other hand, urea reacted with the same reagent under the same experimental conditions to yield the known urea derivatives 3. A new synthesis of polyfunction pyridine via reaction of 1a with malononitrile in presence of aniline could be developed. Similar to the behaviour of 1a, Compounds 1b, c reacted with malononitrile in presence of aniline to yield compounds 8 and 9. In contrast to the behaviour of compounds 1a–c, 1d reacted with malononitrile to yield the malononitrile derivatives 10 or 11 based on the reaction conditions. Mechanisms to account for formation of the reaction products were suggested.
Databáze:	OpenAIRE
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