Reirradiation in Head and Neck Cancer: A Curative Intent in Recurrence or Second Tumors
| Autor: | Gustavo Ossola Lentatia, Enrique Jurado Martín, Vladimir Suarezb, Lourdes de la Peña, Jerónimo Pachon Ibañezb, Ismael Herruzo Cabrera, Maria José Ortiz Gordillob |
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| Rok vydání: | 2016 |
| Předmět: |
Curative intent
medicine.medical_specialty business.industry Head and neck cancer Cancer medicine.disease Omics Acute toxicity Surgery 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine 030212 general & internal medicine business Chronic toxicity Cohort study Head and neck carcinoma |
| Zdroj: | Journal of Nuclear Medicine & Radiation Therapy. |
| ISSN: | 2155-9619 |
| DOI: | 10.4172/2155-9619.1000281 |
| Popis: | Purpose: To assess the efficacy and safety of reirradiation in head and neck cancer and potential prognostic factors associated. Material and methods: Cohort study of patients treated with curative reirradiation for recurrence or second primary tumor. The analysis of RR is obtained prospectively from the database available at both centers. Statistical analysis was performed using the R Commander 2.0 software. Results: Between 2006 and 2013, 40 patients with head and neck carcinoma were reirradiated. The mean dose was 66.39 Gy. 35% of patients showed acute toxicity grade 3 or higher and 20.5% showed chronic toxicity grade 2 or higher. The median follow-up was 11 months. The overall survival at 2 years was 41%; disease free survival and locoregional control at 1 year was 35.9% and 41.1% respectively. The time between treatments and disease-free interval to death and local recurrence were statistically significant (p < 0.05); and the first treatment scheme to distant metastases. |
| Databáze: | OpenAIRE |
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