Oligodeoxyribonucleotide phosphorothioates kill procyclic Trypanosoma brucei brucei: Quantitative determination of their LD50
| Autor: | Caroline Bouzin, Catherine Berens, Dominique Cottem, S Brouckaert, Etienne Sonveaux |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
biology
Antiparasitic medicine.drug_class Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Kinetoplastida Trypanosoma brucei biology.organism_classification Biochemistry Quantitative determination In vitro Alamar blue Deoxyribonucleotide chemistry.chemical_compound Sequence dependent Drug Discovery medicine Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:2071-2076 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00362-4 |
| Popis: | Phosphorothioates kill the procyclic form of T. brucei brucei by a non antisense but sequence dependent effect. The alamar Blue(TM) method allowed an easy microscale determination of their antiparasitic effect. The LD50 of the sequences tested was in the range of 11-20 mu M. (C) 1997 Elsevier Science Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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