Combined effect of mercuric ion and silver ion on the clotting time of blood

Autor: R.R. Arora, D. Kristol, U.R. Phatak, C.R. Spillert
Rok vydání: 2003
Předmět:
Zdroj: 2003 IEEE 29th Annual Proceedings of Bioengineering Conference.
DOI: 10.1109/nebc.2003.1216091
Popis: The mercuric ion (Hg/sup 2+/) has been shown to have a procoagulant effect on citrated whole blood through its excitation of the extrinsic pathway. The silver ion (Ag/sup +/) affects the intrinsic pathway of blood coagulation also producing a shortened clotting time. This in vitro study involved mixing citrated whole blood (CWB) with mercuric nitrate Hg(NO/sub 3/)/sub 2/, silver nitrate AgNO/sub 3/, and the combination of the two. The eight samples were incubated for ten minutes at 37/spl deg/C and were analyzed by an Amelung KC 4A clot detector. The results show that the combination of Ag/sup +/ and Hg/sup 2+/ significantly reduces the clotting time (p
Databáze: OpenAIRE