Abstract PR07: Impact of race on the uterine microbiome in women with early stage endometrial cancer
| Autor: | Andrew F. Olshan, Temitope O. Keku, Gabrielle Hawkins, Jeffrey Roach, Amber N. McCoy, Victoria L. Bae-Jump, Wendy R. Brewster, Russell Broaddus |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 29:PR07-PR07 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1538-7755.disp20-pr07 |
| Popis: | Introduction: African American (AA) women suffer a higher mortality from endometrial cancer (EC) than non-Hispanic white (NHW) women. Potential biological causes for this disparity in AA women include a higher risk of more lethal histologic/molecular subtypes and greater rates of obesity. We hypothesize that another biological factor driving his racial disparity is the uterine microbiome. Thus, we evaluated the microbiota of human ECs and assessed for variations by race. Methods: Banked tumor specimens of post-menopausal patients undergoing hysterectomy for early stage endometrioid ECs were identified. Tumors were analyzed from AA and NHW women and stratified as obese (BMI≥30kg/m2) or non-obese (BMI Citation Format: Gabrielle M. Hawkins, Amber N. McCoy, Andrew Olshan, Russell Broaddus, Wendy R. Brewster, Jeffrey Roach, Temitope Keku, Victoria L. Bae-Jump. Impact of race on the uterine microbiome in women with early stage endometrial cancer [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PR07. |
| Databáze: | OpenAIRE |
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