Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive elderly
Autor: | Daniel Staudenraus, Siddhesh Sapre, Iiris Virta, Heike Hirseland, Dennis DasGupta, Axel Schulz, Addi Romero Olmedo, Carina Münch, Svenja Hochstäter, Christian Keller, Bärbel Camara, Michael Lohoff, Henrik E. Mei, Véronique Hefter |
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Rok vydání: | 2021 |
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Popis: | Herein, we compared SARS-CoV-2-specific antibody and T-cell responses to two doses of BNT162b2 mRNA in 51 vaccinees > 80 years old and 46 (20–53 years old) controls. The responses of the elderly were much lower and 10% non-responders were identified. Importantly, in four of them, a third vaccination raised the immune response to levels seen in responders after two vaccinations, thus implying that non-response is not fateful even in the elderly. |
Databáze: | OpenAIRE |
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