Effect of chlorin e6 and photosensitizer-superoxide dismutase complexes on ion-transporting processes of blood cells

Autor: Armen V. Gyulkhandanyan, Vladimir A. Hovhannisyan, Hakop K. Karagulyan, Margarita M. Korkhmazyan, Grigor Gyulkhandanyan, Anatoly P. Losev
Rok vydání: 1997
Předmět:
Zdroj: Photochemotherapy: Photodynamic Therapy and Other Modalities III.
ISSN: 0277-786X
DOI: 10.1117/12.297820
Popis: The interaction of aromatic amino acids, superoxide dismutase (SOD) and bovine serum albumin (BSA) with chlorin e6 (Chl) and formation of complexes were studied. The decrease of the efficiency of photochemical destruction in the absence of oxygen was observed. The changes of SOD absorption spectra in UV region agree with our former results on irreversible decrease of protein's tryptophan (Trp) luminescence under irradiation. At the same time no changes in enzymatic activity of irradiated SOD in the presence of Chl were detected. The irradiation effect on K+ and H+ ions movement across the membrane of erythrocytes loaded with Chl was studied.© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Databáze: OpenAIRE