Antioxidant and anti-inflammatory effect of the methanolic extracts of Potentilla chinensis
| Autor: | Chan Ho Oh, Hoon Jeon, Hee Kyung Jang, Un-Ki So, Jin Kyu Kim, Jung Il Nam |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
animal structures
Antioxidant urogenital system Chemistry medicine.drug_class medicine.medical_treatment Oxidative phosphorylation Pharmacology Inhibitory postsynaptic potential Anti-inflammatory Pathophysiology Nitric oxide chemistry.chemical_compound Complementary and alternative medicine Biochemistry embryonic structures medicine No production skin and connective tissue diseases Potentilla chinensis |
| Zdroj: | Oriental Pharmacy and Experimental Medicine. 11:137-142 |
| ISSN: | 2211-1069 1598-2386 |
| DOI: | 10.1007/s13596-011-0014-6 |
| Popis: | Potentilla chinensis has been widely used as a traditional medicine for the treatment of many diseases. In macrophages, nitric oxide (NO) released as an inflammatory mediator and has been proposed an important modulator of many pathophysiological conditions. In the present study, we investigated the inhibitory effects of methanol extracts of P. chinensis (PCM) on NO production in mouse (C57BL/6) peritoneal macrophages. PCM suppressed IFN-γ and LPS-induced NO production independent of iNOS expression. Interestingly, iNOS enzyme activity was reduced by PCM treatment. On the contrary to iNOS, cyclooxygenase-2 (COX-2) expression was attenuated by PCM significantly. PCM also demonstrated potent radical scavenging activity and reducing power. The present results indicate that PCM’s inhibitory action on the NO production is not due to attenuation of iNOS expression but direct scavenging of NO radical. These results suggest that PCM may be beneficial in diseases which related to oxidative stress-mediated inflammatory disorders such as rheumatoid arthritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink