In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment
| Autor: | Yoshihiko Kanno, Tetsuya Suzuki, Masamitsu Nakayama, Norihisa Miki, Takashi Ota |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Diamond-like carbon Nanoporous medicine.medical_treatment 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Artificial kidney 01 natural sciences 0104 chemical sciences Dialysis tubing body regions Nanopore Membrane Chemical engineering Hemofiltration medicine Surface modification 0210 nano-technology human activities |
| Zdroj: | 2018 IEEE Micro Electro Mechanical Systems (MEMS). |
| DOI: | 10.1109/memsys.2018.8346575 |
| Popis: | In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney. |
| Databáze: | OpenAIRE |
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