The use of perfluorinated emulsion for prolongation of the endurance period in lethal hypoxia

Autor:	Shilov Vv, Skorik Vi, V. V. Zuev, Sudus Av
Rok vydání:	1997
Předmět:	Oxygen supply Membrane oxygenator Chemistry Apnea General Medicine Hypoxia (medical) Plasma Substitutes General Biochemistry Genetics and Molecular Biology Microcirculation Anesthesia Emulsion medicine medicine.symptom Perfusion
Zdroj:	Bulletin of Experimental Biology and Medicine. 124:1042-1045
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02446856
Popis:	The apnea model with venovenous perfusion and blood oxygenation in a membrane oxygenator was used to study the gas transport characteristics of perfluorinated emulsion with the aim to prolong the endurance period in lethal hypoxia. The use of PFOS emulsion (40 ml/kg) as a hemodilution agent at relatively low rate of assisted perfusion (35 ml/kg×min) produced no improvement of oxygen supply during the critical period in comparison with conventional plasma substitutes. However, perfusion with oxygenated perfluorinated emulsion prolonged survival as compared with polyglucin perfusion, mainly due to the maintenance of the vitally important organs (heart and brain) and due to the improvement of microcirculation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ea14112d7638633b98046f8be427d38c https://doi.org/10.1007/bf02446856 Zobrazit plný text záznamu Full text from SpringerLink