Detonation Nanodiamonds as Promising Drug Carriers

Autor:	G. V. Lisichkin, P. G. Mingalev, R. Yu. Yakovlev, N.B. Leonidov
Rok vydání:	2020
Předmět:	Pharmacology chemistry.chemical_classification Biocompatibility 010405 organic chemistry Biomolecule Pharmacology toxicology Detonation Nanotechnology Specific adsorption 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Specific surface area Drug Discovery Drug carrier
Zdroj:	Pharmaceutical Chemistry Journal. 54:389-403
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-020-02210-1
Popis:	Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ea13df8204db82622d37d11ca9c2a390 https://doi.org/10.1007/s11094-020-02210-1 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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