Autor: B. Johanes, K. Garib, H. K. Gunga, Rainer Lang, H. Gochlen-Koch, K. O. Kirsch, E. Kim, A. Maye, Irina M. Larina, Jens Titze
Rok vydání: 2003
Předmět:
Zdroj: Human Physiology. 29:595-605
ISSN: 0362-1197
Popis: According to the generally accepted view, sodium accumulation in the human body takes place in the extracellular space and is accompanied by an increase in the rate of fluid retention and body weight gain. However, this view was revised in recent studies, which demonstrated that sodium could be accumulated in the human body without expansion of the extracellular space. Sodium exchange and its effect on body weight (BW) were investigated in long-term balance studies. Three apparently healthy volunteer subjects were confined for 135 days to a ground-based model of the main unit of the Mir space station, where they were exposed to model conditions similar to conditions of actual long-term spaceflight. The daily balance of sodium and its contribution to BW changes were studied. During the period of observation, the subjects accumulated 2.973–7.324 mmol of sodium and gained 5.1–9.3 kg. Initially, there was a positive correlation between changes in the total body sodium and the BW, which reflected sodium-dependent extracellular space expansion. However, by the end of the period of isolation, the relative rate of body weight gain was lower than the relative rate of gain in the total body sodium, which suggested that sodium accumulated in an osmotically inactive form. The fact that sodium accumulated without BW gain suggests that isolation of healthy subjects in a hermetically sealed enclosure stimulates sodium accumulation in the body in an osmotically inactive form. The sodium-storing processes activated under these conditions might be localized in bone, connective tissue (skin), or cartilage. Rhythmic variation in the net sodium balance was observed and attributed to oscillations of renal excretion of aldosterone. It is obvious that the depot of osmotically inactive sodium should be taken into account in studies of cardiovascular system function and in pathophysiological approaches to edematous syndrome and hypertension.
Databáze: OpenAIRE
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