Synthesis of Enantiopure 1-r-Alkyl-2-c,5-t-Diphenylphospholanes and Phospholanium Salts through Direct Alkylation of Phospholane

Autor:	Jean-Claude Fiaud, Amelie Duraud, Martial Toffano, Cristian Dobrota
Rok vydání:	2008
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Enantiopure drug Transition metal Chemistry Organic Chemistry Phosphonium Physical and Theoretical Chemistry Alkylation Medicinal chemistry Alkyl
Zdroj:	European Journal of Organic Chemistry. 2008:2439-2445
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200800070
Popis:	Chiral enantiopure 1-alkyl-2,5-diphenylphospholanium salts were obtained in one step through alkylation of phospholane with alkyl triflates. The resulting air-stable phosphonium salts are electron-rich trialkylphosphane precursor ligands for transition metals, and they offer a convenient route toward chiral quaternary phosphonium salts as phase-transfer agents.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze:	OpenAIRE
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