PREPARATION AND ENANTIOSEPARATION OF COPOLYMER CHIRAL STATIONARY PHASES WITH (1R,2R)-(+)-1,2-DIPHENYLETHYLENEDIAMINE AS THE CHIRAL BUILDING BLOCK

Autor:	Shi-Rong Li, Jun Chen, Jun-Yi Zhang, Zheng-Wu Bai, Chuan-Qi Yin
Rok vydání:	2009
Předmět:	Chromatography Diphenylethylenediamine Silica gel Normal phase Clinical Biochemistry Pharmaceutical Science Block (periodic table) Biochemistry Toluene Analytical Chemistry chemistry.chemical_compound chemistry Phase (matter) Copolymer Terephthaloyl chloride
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 33:46-60
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826070903430076
Popis:	(1 R,2 R)-(+)-1,2-Diphenylethylenediamine was copolymerized with terephthaloyl chloride and toluene 2,4-diisocyanate at different fed ratios to give two polymeric chiral selectors. The selectors were immobilized onto 3-aminopropyl silica gel to afford corresponding chiral stationary phases. The enantioseparation evaluation reveals the shorter-chain polymeric selector possesses better enantioseparation ability. In normal phase mode, tert-butanol is advantageous for enantioseparation when it is used as one of the mobile phase compositions. The influence of other aspects including selector structure, sample loading and temperature on the enantioseparation ability of these chiral stationary phases was also studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e9f677c271028a6b26c365480dc39029 https://doi.org/10.1080/10826070903430076 Zobrazit plný text záznamu