Smart nanostructures for targeted oxygen-producing photodynamic therapy of skin photoaging and potential mechanism
| Autor: | Yun Wang, Zhaopeng Lu, Yuqi Huang, Wenyu Jia, Wandong Wang, Xin Zhang, Cheng Chen, Yizhi Li, Chunsheng Yang, Guan Jiang |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Nanomedicine. 18:217-231 |
| ISSN: | 1748-6963 1743-5889 |
| Popis: | Background: Photodynamic therapy increases collagen and decreases solar fibrosis in photoaged skin; however, the efficacy of photodynamic therapy is limited in tissues with a hypoxic microenvironment. Methods: A novel autogenous oxygen-targeted nanoparticle, named MCZT, was synthesized based on the zeolitic imidazole framework material ZIF-8, methyl aminolevulinate, catalase and an anti-TRPV1 monoclonal antibody, and its effects on skin photoaging were investigated. Results: MCZT was successfully synthesized and showed uniform particle size, good dispersion, and excellent biocompatibility and safety. Moreover, MCZT effectively alleviated UV-induced inflammation, cellular senescence and apoptosis in HFF-1 cells. In in vivo models, MCZT ameliorated UV-evoked erythema and wrinkling, inflammation and oxidative stress, as well as the loss of collagen fibers and water, in the skin of mice. Conclusion: These findings suggest that MCZT holds promising potential for the treatment of skin photoaging. |
| Databáze: | OpenAIRE |
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