Apoptosis and autophagy in hepatocarcinoma cells induced by different forms of lithium salts
| Autor: | Vladimir I. Konenkov, Alexander Lykov, N. P. Bgatova, Yu. I. Borodin, A. O. Solovieva, V. V. Makarova, Yu. S. Gavrilova |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Programmed cell death medicine.diagnostic_test Lithium (medication) Lithium carbonate Autophagy Cell Biology Biology medicine.disease digestive system diseases Flow cytometry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Biochemistry Apoptosis Cell culture Hepatocellular carcinoma medicine Cancer research neoplasms 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cell and Tissue Biology. 11:261-267 |
| ISSN: | 1990-5203 1990-519X |
| Popis: | Hepatocellular carcinoma (HCC) is one of the aggressive and resistant to drug therapy cancer. It is believed that the development of HCC is correlated with dysregulation of programmed cell death. So, the search for effective inducers of HCC cell death is very important. The aim of the work was to identify structural changes leading to HCC cell death when exposed to nanoscale and original forms of lithium salts. Using light and electron microscopy and flow cytometry, structural features of autophagy and apoptosis in HCC cells after their incubation with various forms of lithium salts has been revealed. It is shown that a more pronounced effect on HCC-29 cells have nanoscale forms of lithium carbonate and lithium citrate. At the same time, nanoscale lithium citrate mainly induced apoptosis, and nanosized form of lithium carbonate, along with apoptosis, induced autophagic death of HCC-29cells. |
| Databáze: | OpenAIRE |
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