Participation of adrenal hormones in the genesis of arterial hypertension of hypothalamic origin
| Autor: | K. V. Sudakov, V. F. Tyabenkova, V. S. Bakulin, T. D. Bol'shakova, A. F. Bunatyan, V. V. Men'shikov |
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| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure business.industry Adrenalectomy medicine.medical_treatment Stimulation General Medicine General Biochemistry Genetics and Molecular Biology Endocrinology Blood pressure Epinephrine Hypothalamus Internal medicine medicine business Adrenal hypertension medicine.drug Hydrocortisone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 81:480-483 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Continuous electrical stimulation for many hours of hypothalamic negative emotiogenic centers (the ventromedial nuclei) evoked persistent arterial hypertension with a characteristic phasic dynamics of adrenal secretory activity in waking, immobilized rabbits. Bilateral extirpation of the adrenals lowered the original level of the mean arterial pressure and inhibited the development of persistent arterial hypertension. Stimulation of the above-mentioned hypothalamic structures for many hours in adrenalectomized rabbits, in conjunction with administration of hydrocortisone and adrenalin, evoked persistent arterial hypertension again. After administration of hydrocortisone and adrenalin separately to adrenalectomized rabbits, stimulation of the ventromedial hypothalamic nuclei for many hours resulted in only a transient rise of blood pressure. It is concluded that an essential role in the formation of persistent arterial hypertension in rabbits during continuous stimulation of the hypothalamic negative emotiogenic centers for many hours is played by activation of adrenal cortical and medullary hormones. |
| Databáze: | OpenAIRE |
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