Deprotection of 4-Methoxybenzyloxycarbonyl Group withp-Toluenesulfonic Acid in Acetonitrile. Application to a Large-scale Preparation of 7-[D-2-Amino-2-(4-hydroxyphenyl)acetamido]cephalosporanic Acid

Autor:	Ueda Shinji, Hirotada Yamada, Takenari Nakagome, Hiroyuki Suzuki, Hisao Tobiki, Kiyokazu Jimpo, Norihiko Tanno
Rok vydání:	1984
Předmět:	chemistry.chemical_compound chemistry Bicyclic molecule Lactam p-Toluenesulfonic acid Organic chemistry General Chemistry Phenols Protecting group Acetonitrile Ritter reaction
Zdroj:	Bulletin of the Chemical Society of Japan. 57:3333-3334
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.57.3333
Popis:	The 4-methoxybenzyloxycarbonyl group of 7-[D-2-(4-hydroxyphenyl)-2-(4-methoxybenzyloxycarbonylamino)acetamido]cephalosporanic acid was effectively removed with p-toluenesulfonic acid in acetonitrile. The mechanism of the deprotection is discussed and the role of acetonitrile can reasonably be explained in terms of the Ritter reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e9db8d4fb29d091d481b7f21a0353966 https://doi.org/10.1246/bcsj.57.3333 Zobrazit plný text záznamu