High levels of donor-derived cell-free DNA in a case of graft-versus-host-disease following liver transplantation
| Autor: | Duncan Lewis, Thiago Beduschi, Joanna Chaffin, Robert Woodward, Jake Miles, Sergio Duarte, Ali Zarrinpar, Leah J Hooey, Natali Gulbahce, Renata Glehn-Ponsirenas |
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| Rok vydání: | 2022 |
| Předmět: |
Oncology
Transplantation medicine.medical_specialty business.industry medicine.medical_treatment Clinical course Liver transplantation medicine.disease Response to treatment Immune state surgical procedures operative Graft-versus-host disease Cell-free fetal DNA Internal medicine medicine Immunology and Allergy Pharmacology (medical) Donor derived Solid organ transplantation business |
| Zdroj: | American Journal of Transplantation. 22:973-976 |
| ISSN: | 1600-6135 |
| Popis: | The diagnosis of graft-versus-host-disease (GVHD) after solid organ transplantation is made difficult by its variable clinical presentation and lack of sensitive and specific biomarkers to evaluate the immune state of transplant recipients. Emerging noninvasive diagnostic techniques like the quantification of donor-derived cell-free DNA (dd-cfDNA) for surveillance may improve the current standard-of-care. Herein, we report the use of this methodology in a patient with GVHD and corresponding levels of dd-cfDNA without any evidence of graft injury. Correlation of dd-cfDNA levels with the clinical course and its novel application here could lead to improvements in the rapid diagnosis of GVHD and in monitoring of response to treatment. |
| Databáze: | OpenAIRE |
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