| Autor: |
Georgios I. Tsiaoussis, Konstantinos Thomopoulos, Athanassios C. Tsamandas, Constantine E Vagianos, Christos Triantos, Iris Spiliopoulou, Vassiliki N Nikolopoulou, Chrisoula D. Scopa, Valeria Kaltezioti, Elli Karatza, Aristidis Charonis, Stelios F Assimakopoulos |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Investigation. 42:439-446 |
| ISSN: |
0014-2972 |
| Popis: |
Eur J Clin Invest 2012; 42 (4): 439–446 Abstract Background Increased intestinal permeability in cirrhosis exerts a pivotal role in the pathogenesis of spontaneous bacterial peritonitis and other complications of cirrhosis through promotion of systemic endotoxemia. This study was designed to investigate whether the expression of tight junction (TJ) proteins, which regulate gut paracellular permeability, is altered in the intestinal mucosa of patients with liver cirrhosis and study its potential association with the stage of liver disease and the development of systemic endotoxemia. Design Twenty-four patients with cirrhosis at a decompensated (n = 12, group A) or compensated condition (n = 12, group B) and 12 healthy controls (group C) were subjected to duodenal biopsy. The expression of the TJ proteins occludin and claudin-1 in the intestinal epithelium was evaluated by immunohistochemistry. Plasma endotoxin concentrations were also determined. Results Patients with cirrhosis presented significantly higher serum endotoxin concentrations as compared to healthy controls (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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