A new 22,26-seco physalin steroid from Physalis angulata
| Autor: | Jutatip Boonsombat, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop, Sanit Thongnest, Pornsuda Chawengrum |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry medicine.medical_treatment Organic Chemistry Physalis angulata Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Steroid HeLa 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Cell culture Toxicity medicine Physalin Cytotoxicity Dichloromethane |
| Zdroj: | Natural Product Research. 34:1097-1104 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1550766 |
| Popis: | A new 22,26-seco physalin, physalin XI (1) together with 5 known compounds, were isolated from the dichloromethane extract of Physalis angulata L. The structure of isolated compounds was elucidated by spectroscopic analysis. The effects of isolated compounds on in vitro cytotoxicity were investigated. Compound 1 was assessed for its cytotoxicity against cancer cell lines (HepG2, HeLa, HuCCA-1, T47-D and A-549) and a normal cell line (MRC-5), and the result showed that it has no activity. Compounds 2 and 4 are highly toxic to H69AR and MDA-MB-23 cell lines. This property appears to be related to the presence of their conjugated double bond or epoxy groups and is a more reliable indication of toxicity than substitution on C(5)-C(6). |
| Databáze: | OpenAIRE |
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