Benefit and cost from the long-term use of cyclosporine-A in idiopathic membranous nephropathy
| Autor: | Florentia Sotsiou, John G. Vlachojannis, Pantelitsa Kalliakmani, Dimitrios S. Goumenos, Eleni Koutroulia |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Renal function Glomerulonephritis General Medicine medicine.disease Gastroenterology Nephrotoxicity Membranous nephropathy Nephrology Internal medicine Cyclosporin a Immunology Biopsy Prednisolone Medicine business Nephrotic syndrome medicine.drug |
| Zdroj: | Nephrology. 15:762-767 |
| ISSN: | 1320-5358 |
| Popis: | Aim: Idiopathic membranous nephropathy (IMN), the most common cause of nephrotic syndrome in adults, is usually treated by cyclosporin A (CsA). Estimation of the effectiveness of long-term use of CsA in the remission and relapse rate of nephrotic syndrome along with histological changes in repeat renal biopsies was the aim of the study. Methods: Thirty-two nephrotic patients with well-preserved renal function treated by prednisolone and CsA were studied. A repeat biopsy was performed in 18 patients with remission of nephrotic syndrome, after 24 months of treatment, to estimate the activity of the disease and features of CsA toxicity. Results: Complete remission of nephrotic syndrome was observed in 18 (56%) and partial remission in 10 patients (31%) after 12 months of treatment (total 87%). Relapses were observed in 39% and 60% of patients with complete and partial remission, respectively, and multiple relapses in 25% of patients, who showed gradual unresponsiveness to CsA and decline of renal function. Progression of stage of the disease and more severe glomerulosclerosis and tubulointerstitial injury were recognized in 55% and 61% of patients respectively. Features of CsA nephrotoxicity were not observed. The severity of histological changes was related to the time elapsed from the first biopsy (r = 0.452, P |
| Databáze: | OpenAIRE |
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