ChemInform Abstract: Synthesis and Inhibitory Properties of α(Chlorofluoromethyl)-α-amino Acids, a Novel Class of Irreversible Inactivators of Decarboxylases

Autor:	Jean-Bernard Ducep, Joseph Wagner, Daniel Schirlin, J. Fischer, J. M. Hornsperger, A. Mitschler, Raymond Weiss, Jean-Georges Heydt, Philippe Bey, Michel Jung, S. Baltzer, Charles Danzin, A. De Cian, F. Piriou
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Aromatic L-amino acid decarboxylase chemistry Stereochemistry Glutamate decarboxylase Diastereomer Absolute configuration General Medicine Glutamic acid Enantiomer Ornithine decarboxylase Amino acid
Zdroj:	ChemInform. 23
ISSN:	0931-7597
Popis:	The synthesis of α-(chlorofluoromethyl)-ornithine 7, -metatyrosine 8 and -glutamic acid 14 is described. Separation of diastereoisomers and relative configuration assignment by X-ray analysis are reported. Assignment of absolute configuration of the four enantiomers of α-(chlorofluoromethyl)-ornithine 7 is also described. The inhibitory properties against ornithine decarboxylase, aromatic amino acid decarboxylase and glutamate decarboxylase are reported in terms of diastereoselectivity (8 and 14) or enantioselectivity (7).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e9b50063110e01570c6a01ef3b5896d9 https://doi.org/10.1002/chin.199233262 Zobrazit plný text záznamu Plný text