Mechanisms of progressive glomerulosclerosis and tubulointerstitial fibrosis
| Autor: | Stuart J. Shankland, James Bassuk, Christian Hugo, Leah Haseley, William G. Couser, Raimund Pichler, Shinichi Suga, Richard J. Johnson, Susan Thomas |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Mesangial cell biology Physiology business.industry Growth factor medicine.medical_treatment Glomerulosclerosis medicine.disease Cell biology Extracellular matrix Endocrinology Nephrology Physiology (medical) Internal medicine Thrombospondin 1 Tubulointerstitial fibrosis medicine biology.protein business Platelet-derived growth factor receptor Transforming growth factor |
| Zdroj: | Clinical and Experimental Nephrology. 2:307-312 |
| ISSN: | 1437-7799 1342-1751 |
| Popis: | In this paper we provide an overview of the cellular changes that accompany progressive glomerulosclerosis and tubulointerstitial fibrosis. Emphasis is placed on the role of platelet-derived growth factor (PDGF) in the proliferation of the mesangial cell and interstitial fibroblast. PDGF also stimulates the synthesis and expression of a protein called secreted protein acidic and rich in cysteine (SPARC) and of thrombospondin 1 (TSP1). TSP1 may have an important role in the conversion of transforming growth factor (TGF)-β from its latent to active form. In turn, TGF-β appears to have a major role in mediating the extracellular matrix deposition that occurs with progressive glomerular and interstitial scarring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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