Acute toxicity test of 96% ethanol extract of Syzygium myrtifolium leaves in white mice (Mus musculus)
| Autor: | Kevin Christofer Fadillah, Lusi Indriani, E. Mulyati Effendi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Thorax
Ethanol biology Toxin business.industry Pharmaceutical Science Pharmacy Abdominal cavity Pharmacology medicine.disease_cause biology.organism_classification Median lethal dose Acute toxicity 030205 complementary & alternative medicine Education 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Oral administration Syzygium 030220 oncology & carcinogenesis medicine business |
| Zdroj: | Pharmacy Education. :201-204 |
| ISSN: | 1477-2701 |
| DOI: | 10.46542/pe.2021.212.201204 |
| Popis: | Introduction: Acute toxicity effects appear within a short time following the oral administration of either a single dose or repeated doses of toxin within 24 hours. Acute toxicity testing involves the administration of a range of doses across several groups of experimental animals with one dose administered per group, followed by the observation of toxic effects and mortality. Objectives: The purpose of this study was to determine the lethal dose 50 (LD50) and acute toxicity of an ethanol extract of Syzygium myrtifolium leaves in white mice. Methods: Exposed groups consisted of a negative control group (carboxymethylcellulose sodium) and four treatment groups (500, 1000, 2000, and 4000 mg/kg body weight (bw)). Mortality was observed for 14 days following oral administration. Results: The results demonstrated an LD50 of 1995 mg/kg bw, categorised as moderately toxic. Observed toxic effects included white lesions in the lungs, blackened liver, organ swelling, and fluid accumulation in the abdominal cavity and thorax. |
| Databáze: | OpenAIRE |
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