Physicochemical properties of (R)- vs (S)-methylphosphonate substitution on antisense DNA hybridization determined by free energy perturbation and molecular dynamics

Autor:	Jeffrey D. Saxe, B. G. Rao, U. C. Singh, Frederick H. Hausheer
Rok vydání:	1992
Předmět:	Antisense DNA Chemistry Diastereomer General Chemistry Biochemistry Genome Catalysis Molecular hybridization Free energy perturbation Molecular dynamics chemistry.chemical_compound Colloid and Surface Chemistry Complementary DNA Biophysics DNA
Zdroj:	Journal of the American Chemical Society. 114:3201-3206
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00035a005
Popis:	Methylphosphonate (MP)-substituted antisense DNA oligomers have significant potential for genome targeted therapy. The physicochemical basis of the difference in R-versus S-MP diastereomers incorporated into DNA oligomers with regard to complementary DNA target hybridization has been poorly understood. State of the art advanced molecular computational methods and supercomputer technology were applied to identify key physicochemical determinants involved in stabilizing and destabilizing target hybridization
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e9a65b6535cc45de12187711eeffb1c9 https://doi.org/10.1021/ja00035a005 Zobrazit plný text záznamu