Antimalarial Properties ofMorinda lucidaandAlstonia booneion Sulphadoxine-Pyrimethamine andCurcuma longaon Quinine in Mice
| Autor: | J.M. Agbedahunsi, Adeteju A. Adedini, Adesegun Adepitan, Awodayo O. Adepiti, Olutola Akinsomisoye |
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| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
Quinine biology ved/biology 030231 tropical medicine ved/biology.organism_classification_rank.species biology.organism_classification medicine.disease 03 medical and health sciences 0302 clinical medicine Complementary and alternative medicine Sulphadoxine-pyrimethamine Morinda lucida medicine Plasmodium berghei 030212 general & internal medicine Curcuma Alstonia boonei Malaria medicine.drug |
| Zdroj: | Journal of Herbs, Spices & Medicinal Plants. 22:1-10 |
| ISSN: | 1540-3580 1049-6475 |
| DOI: | 10.1080/10496475.2014.999151 |
| Popis: | The antimalarial activities of Morinda lucida (MLE), Alstonia boonei (ABE), Curcuma longa (CLE) at 12.5–400 mg kg−1, sulphadoxine-pyrimethamine (S-P), and quinine at 0.2–1.7 and 0.625–10 mg kg−1, respectively, were investigated in Plasmodium berghei–infected mice using the 4-d malaria test. Assessment of MLE plus S-P, ABE plus S-P, and CLE plus quinine was similarly done. Dose-dependent activities were noted with MLE, ABE, and CLE with chemosuppression values of 39.8–90.5, 0.2–74.8, and 34.6–78.4%, respectively. The combinations gave 1.8- to 2.5-fold greater chemosuppression than the individual drug/extracts. The efficacies of S-P and quinine were enhanced when combined with the extracts. |
| Databáze: | OpenAIRE |
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