DBU-catalyzed Michael addition of bulky glycine imine to α,β-unsaturated isoxazoles and pyrazolamides
| Autor: | Ping-An Wang, Ya-Jun Bai, Xiao-Hui Zheng, Yu-Jun Bai, Mei-Ling Cheng, Sheng-Yong Zhang, Xiao-Mu Hu |
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| Rok vydání: | 2021 |
| Předmět: | |
| DOI: | 10.3762/bxiv.2021.18.v1 |
| Popis: | A DBU-catalyzed Michael additions of several pronucleophiles with high pK a values including bulky glycine imines, α-tetra-lone, 1-methyl-2-indolone and nitroalkanes to α,β-unsaturated isoxazoles and pyrazolamides have been realized in THF with 1.0 eq. LiBr as a additive at room temperature within 3 h to provide Michael adducts in excellent yields (up to 97%) and diastereoselectivities (> 20:1). |
| Databáze: | OpenAIRE |
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