BRIEF COMMUNICATION: Serum concentrations of monocyte chemoattractant protein-1 in healthy and critically ill dogs

Autor: Amanda L. Duffy, Dahlia M. Rice, Steven W. Dow, James Eucher, Francisco Olea-Popelka
Rok vydání: 2010
Předmět:
Zdroj: Veterinary Clinical Pathology. 39:302-305
ISSN: 0275-6382
Popis: Background: The chemokine monocyte chemoattractant protein-1 (MCP-1) is a primary regulator of monocyte mobilization from bone marrow, and increased concentrations of MCP-1 have been associated with sepsis and other inflammatory disorders in critically ill people. The relationship between MCP-1 and disease in dogs has not been evaluated previously. Objective: The purpose of this study was to assess serum concentrations of MCP-1 in healthy dogs, dogs in the postoperative period, and critically ill dogs. We hypothesized that MCP-1 concentrations would be significantly increased in critically ill dogs compared with postoperative or healthy dogs. Methods: Serum concentrations of MCP-1 were measured in 26 healthy control dogs, 35 postoperative dogs, and 26 critically ill dogs. Critically ill dogs were further subgrouped into dogs with sepsis, parvovirus gastroenteritis, immune-mediated hemolytic anemia, and severe trauma (n=26). MCP-1 concentrations were determined using a commercial canine MCP-1 ELISA. Associations between MCP-1 concentrations and disease status were evaluated statistically. Results: MCP-1 concentration was significantly higher in critically ill dogs (median 578 pg/mL, range 144.7–1723 pg/mL) compared with healthy dogs (median 144 pg/mL, range 4.2–266.8 pg/mL) and postoperative dogs (median 160 pg/mL, range 12.6–560.4 pg/mL) (P
Databáze: OpenAIRE
Externí odkaz: