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Transbronchial biopsy is required for evaluation of some patients with interstitial lung disease (ILD). The diagnostic success of histopathologic assessment is variable, and affected by such factors as specimen size and the presence of crush artifact attributable to the use of conventional biopsy forceps. Use of cryoprobes to perform transbronchial biopsy enables larger and better quality samples to be obtained compared with conventional methods. The safety profile of transbronchial cryobiopsy is similar to that of transbronchial biopsy with forceps. Diagnostic success of histopathology seems higher when the cryoprobe is used although multidisciplinary agreement with close interaction between clinicians, radiologist, and pathologist is essential to assess the utility of this transbronchial procedure. Larger multisite randomized trials are required to confirm the potential benefits of transbronchial cryobiopsy. |
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