| Autor: |
Karel Capek, Jan Balzarini, Michel Geoffroy, Martina Zsély, Erik De Clercq, István Komáromi, Jean M. J. Tronchet |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Nucleosides and Nucleotides. 13:1871-1889 |
| ISSN: |
0732-8311 |
| DOI: |
10.1080/15257779408010670 |
| Popis: |
Representative examples of the title compounds including bicyclic analogs (7–9) in which a perhydro-1,3-oxazine is ortho-fused to the furanose ring, have been prepared in good to excellent yields. Compounds 5 and 7 showed marked activity against HIV-1 and HIV-2 replication in CEM cells (50% inhibitory concentration: 0.80–4.3μg/mL). Their di-O-acetylated (6) and mono-O-acetylated (8) derivatives were considerably less effective. To the best of our knowledge, these β-D-threo anti-HIV nucleoside analogs constitute the first examples of anti-HIV active nucleosides bearing this configuration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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