ChemInform Abstract: Hydrolysis of N-(2,2,2-Trichloroethyl)arenesulfonamides

Autor:	T. V. Kashik, Mirskova Anna N, Igor B. Rozentsveig, Galina G. Levkovskaya
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Hydrolysis chemistry Nitrogen atom Heteroatom Substituent Organic chemistry General Medicine Alkaline hydrolysis (body disposal) Cleavage (embryo) Medicinal chemistry Sulfonamide
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200136037
Popis:	The direction of alkaline hydrolysis of N-(2,2,2-trichloro-1-R-ethyl)arenesulfonamides depends on the R substituent in the α-position with respect to the nitrogen atom. Substituents R having an n-donor heteroatom X promote cleavage of the C-N and C-X bonds to release the corresponding sulfonamide. Alkaline hydrolysis of N-(1-aryl-2,2,2-trichloroethyl)arenesulfonamides occurs chemoselectively at the trichloromethyl group. This reaction can be regarded as a preparative route to N-arylsulfonyl-a-arylglycines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e9865bfd31022aa3d7c89021abea5bd0 https://doi.org/10.1002/chin.200136037 Zobrazit plný text záznamu Plný text